Cultured brain microvessel endothelial cells as in vitro models of the blood-brain barrier.
نویسندگان
چکیده
A central nervous system (CNS) site of action generally requires that, following entry into the systemic circulation, substances must interact with the blood-brain barrier (BBB) en route to brain tissue targets. Many substances with CNS activity, including drugs of abuse, cross the BBB by simple passive diffusion (Oldendorf 1974; Levin 1980; Cornford et al. 1982). Accordingly, the BBB plays an important role in regulating access of drugs of abuse to the brain.
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عنوان ژورنال:
- NIDA research monograph
دوره 120 شماره
صفحات -
تاریخ انتشار 1992